SYNFORM ISSUE 2009/8

Supplementary Issue

Supplementary issue

Special Issue

Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis.

The pineal hormone melatonin has been implicated in the circadian regulation of sleep. In a crossover design, we investigated the effect of acute administration of 5 mg melatonin and a melatonin agonist (S-20098, 5 and 100 mg) in healthy young men when given 5 h before bedtime on sleep structure and electroencephalogram (EEG) power density. Each trial comprised a baseline, a treatment, and a po...

Supplementary Issue